Kidney Biomarkers and the Differential Diagnosis and Prognosis of AKI in Patients with Cirrhosis

Overview

Renal dysfunction is a common complication in hospitalized patients with cirrhosis. The diagnosis of Type 1 HRS is one of exclusion and cannot be made until other causes of renal failure, particularly acute tubular necrosis (ATN), are ruled out. The treatment for ATN is solely supportive via hemodialysis, as vasoconstrictors and albumin will not improve renal function and may potentially worsen it. Differentiating between Type 1 HRS and ATN may be difficult and often takes several days, as traditionally-used distinguishing urinary parameters may be altered in advanced liver disease. 

Additionally, determining which patients are at risk for progression of their AKI early in the course of the disease is challenging. Hence, crucial delays in diagnosis impair the ability to institute treatment earlier, which may lead to increased morbidity and mortality. Research in both experimental animals and humans has identified urine biomarkers that are capable of detecting renal tubular injury (a sine qua non for ATN) with a high degree of sensitivity and specificity as well as associating with progression of AKI. 

In this prospective multicenter cohort study, we have to enrolled ~200 patients, from four major academic centers, with cirrhosis and renal dysfunction and are determining the efficacy of urinary IL-18, NGAL, KIM-1, and L-FABP in correctly identifying ATN in hospitalized patients with cirrhosis and renal dysfunction, thereby facilitating the diagnosis of Type 1 HRS. Additionally, we are evaluating the association between these biomarkers and AKI progression and mortality.

Bio Profile

Chirag R Parikh, MD, PhD, FACP

Principal Investigator

Professor of Medicine (Nephrology)

Director, Program of Applied Translational Research

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Bio Profile

Justin Miles Belcher, MD, PhD

Instructor in and Clinical Instructor in Medicine (Nephrology)

Investigator in the Program of Applied Translational Research

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Bio Profile

Guadalupe Garcia-Tsao, MD

Professor of Medicine (Digestive Diseases)

Chief, Digestive Diseases, VA-CT Healthcare System

Director, Clinical and Translational Core, Yale Liver Center

Program Director, VA-CT Hepatitis C Resource Center

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Virginia Commonwealth University 

Arun Sanyal, MD - Co-Investigator


Jacobi Medical Center 

Naheed Ansari, MD - Co-Investigator

AKI Cirrhosis

Contact information

For more information, or if you are interested in collaborating on this study, please contact Justin Belcher.

Project funding

Funding for this project comes, in part, from the following grants:

R21DK078714 (NIH-NIDDK)

"Novel biomarkers to identify acute tubular necrosis in cirrhosis patients with renal dysfunction"